Mentha Topical Solution

Adjuvant treatment for:

tension headache

musculoskeletal pain

nasal congestion

Analgesic and anti-inflammatory properties

The superficial counter-irritant, analgesic and local anti-inflammatory properties of peppermint have been entirely proved. When essential oil of peppermint or menthol is applied to the skin, it simultaneously stimulates the nerves responsible for the sensation of cold and suppresses those that convey pain sensation.

Based on the results of studies carried out on animals, menthol exerts its analgesic effects by activation of endogenous opioid system and/or somewhat local anesthetic properties. Also, peppermint essential oil inhibits muscular contractions caused by serotonin and substance P.

Peppermint essential oil is a cost effective treatment for tension headache and is well tolerated. In a placebo-controlled, randomized, cross-sectional, double-blind clinical trial, the efficacy of 10 g peppermint essential oil in ethanol 90% solution, in treatment of 164 cases of tension headache in 41 male and female patients, was compared with 1 g acetaminophen and placebo. Headache episodes were treated with placebo capsule and peppermint essential oil, acetaminophen and placebo solution, acetaminophen and peppermint essential oil or placebo capsule and placebo solution. Peppermint essential oil was rubbed on the forehead and temples; this was repeated after 15 and 30 minutes. In comparison with the placebo, peppermint essential oil significantly reduced the severity of headache after 15 minutes (p<0.01). Acetaminophen was more efficient compared to placebo (p<0.01), but had no significant difference from peppermint essential oil. Also, simultaneous administration of peppermint essential oil and acetaminophen resulted in a synergistic effect (p<0.001). The researchers came to the conclusion that for treatment of tension headache, peppermint essential oil is a suitable and cost effective alternative for oral painkillers.

In a placebo-controlled, randomized, cross-sectional, double-blind clinical trial, according to the feedback received from the patients and measurement of the activity of temporal muscles using EMG, local application of peppermint essential oil on the forehead and temples resulted in statistically significant reduction of muscular tension. Also, sensitivity towards pain was reduced.

The Commission E in Germany has approved the local application of peppermint essential oil for alleviation of myalgia and neuralgia.

Decongestant properties

Menthol and peppermint essential oil are used in nasal decongestants, lozenges and humidifiers. It seems that their popularity is indicative of their efficacy in facilitating breathing during common cold, their antibacterial properties and rendering the environment unfavorable for viral growth.

For headache:

Rub 5-10 drops of Mentha Topical Solution to the forehead and temples, repeat after 15-30 minutes if necessary.

For musculoskeletal pain:

Rub 5-10 drops of Mentha Topical Solution to the affected area, 3-4 times per day.

For nasal congestion

2-3 times per day, rub 2-3 drops of Mentha Topical Solution on the upper lip or impregnate a clean tissue with few drops and cover the nose with it.

Dosage form

Topical Solution


15 ml drop with dropper in cardboard box

Patient information leaflet inside


  • Essential oil of peppermint (Mentha piperita)

Active Ingredients

  • menthol
  • menthone
  • methyl acetate
  • terpenoids constitute the main substances in essential oil of peppermint

Contraindications and Cautions

In infants and young children, peppermint essential oil should not be applied on the face, especially around the nose. In such cases, glottal and bronchial spasm, asthma-like attacks and respiratory failure might occur.

Use with caution in patients sensitive to salicylates and those with aspirin-induced asthma.

Adverse Effects

Generally, mint, peppermint essential oil and menthol are safe and are categorized as Generally Regarded as Safe (GRAS). Local application of peppermint essential oil with the recommended amounts has showed no adverse reactions; however, contact dermatitis and hypersensitivity reactions may occur.

Drug Interaction

No reported drug interaction.

Administration during Pregnancy and Lactation

The use of this product is allowed during pregnancy (B2) and lactation (CC). However, it is best to avoid any medication during the first trimester of pregnancy.


Further Notes

  • This solution is not edible.
  • Keep Mentha Topical Solution, like all other medication, away from sight and reach of children.
  • Tightly close the container after application and keep the medicine away from light and in 15-30°C.
  • Keep this leaflet; you may need to read it again.

Based on presence of 24-36 mg menthol per ml of the product.