The liver is the main metabolism organ in the human body, through which all the absorbable nutrients pass. Therefore, our nutritional health depends on the liver to a great extent. Nowadays, most nutrients undergo various processes and such processed foods contain many chemicals such as preservatives, color additives, food flavorings as well as remnants of pesticides and growth hormones which are harmful to liver. Such materials are the cause of liver diseases; even a mild liver dysfunction results in extreme exhaustion, feeling a bad taste in the mouth, loss of appetite and aversion to food.
Strawberry is rich in flavonoids and antioxidant compounds. It is also considered as a metabolic cleaner and hepatic stimulant. Vine twigs regulate metabolism of carbohydrates; also, its efficacy for humans is due to its antioxidant effects, which have been demonstrated by the studies conducted on 11 types of vine. This antioxidant potential may be due to the existence of phenol and flavonoid compounds in vine. Therefore, due to the antioxidant compounds present in Hepatoheal Chewable Tablet, it aids the body and the liver against harmful factors.
One study examined the hepatoprotective effect of the ethanol extract of leaves and twigs of vine and its four different components (CHCL3, EtOAc, n-BuOH and the remaining aqueous component) on rat liver acute toxicity induced by Carbon Tetrachloride (CCL4). This study showed that the ethanol extract of leaves and twigs of vine with a dose of 125 mg/kg (orally) was very effective and n-BuOH with a dose of 83 mg/kg manifested significant antioxidant and hepatoprotective properties.
To evaluate the effectiveness of natural treatments on 10 children (2 girls and 8 boys) aged 3-11 with chronic hepatitis type B, in a course of 12 months, Taraxacum Stanno Cultum 0.1 % and Hepar/ Stannum D15/20 were administered in the form of subcutaneous injections in two parts of the arm and the Hepatodoron product (the foreign sample of Hepatoheal tablet, made from the leaves and twigs of vine along with strawberry) was administered orally. Patients were clinically examined every three months, and liver enzymes, hepatitis B virus DNA polymerase activity, and the cellular and hepatitis B virus immune markers were monitored every six months. Based on the results of this study, effectiveness became manifest from the outset of the treatment and the treatment continued for twelve months. After twelve months, in all the patients, hepatitis B virus DNA polymerase activity decreased from 4121.8 cpm to 785 cpm which was statistically significant (p<0.01). There was a serological change in the HBeAg/anti-Hbc markers in %12.5 of patients and a tendency towards normalization of cellular immunity, which was measured by rosette test, was observed in %87.5 of the patients. Such observations showed that chronic hepatitis type B is accompanied with cellular immunity dysfunction and these natural drugs are capable of enhancing cellular immunity in patients with chronic hepatitis B. Moreover, it seems that these natural drugs stop the proliferation of hepatitis B virus and remove the virus from all the infected cells of the liver.
In an in vivo study, the antidiabetic and antioxidant effects of the leaves and twigs of vine were examined in diabetic rats. It was manifested that the ethyl acetate fraction of the aqueous extract is rich in polyphenolic compounds and that they have significant antihyperglycemic and antioxidant effects, which equal the effects of tolbutamide.
To evaluate the antipyretic and anti-inflammatory effects of orally prescribed methanol extract of vine leaves (with doses 100, 200, 400 ml/kg) in rats, the antipyretic effect was examined by creating fever as a result of brewer’s yeast and the anti-inflammatory effect was examined by creating paw edema or induced by carrageenan. The antipyretic effect of this extract started an hour right after it was administered and continued for four hours. Compared to the control group, the methanol extract of vine leaves manifested significant (p<0.01) and dose-dependent anti-inflammatory and antipyretic effects which were less than acetaminophen or diclofenac. Moreover, no consequent acute toxicity was observed as a result of oral administration of this extract with a dose of 2000 ml/kg. The results of this study showed that the methanol extract of vine leaves has antipyretic and anti-inflammatory effects.