Dermatin Topical Cream

Adjuvant treatment for various types of dermatitis (eczema), including atopic dermatitis and irritant contact dermatitis

Christ’s Thorn Jujube (sidr) is endemic to the southern regions of Iran. Its leaves have for years been used for washing the hair and the body and for dyeing of the hair. In Persian Medicine, Christ’s thorn jujube is introduced as an antiseptic, antifungal, anti-inflammatory and conditioning agent and has been used for treatment of skin diseases such as atopic dermatitis (Nafisi, 1989); it also has antimicrobial and antioxidant properties. Furthermore, its role in cosmetics and for treatment of psoriasis has been studied.

In a parallel, double-blind clinical study, 80 patients with irritant contact dermatitis used either a cream containing Christ’s thorn jujube total extract, a cream containing saponinic extract of Christ’s thorn jujube leaves or placebo. The duration of the study was three months. During the treatment with the cream containing saponinic extract of Christ’s thorn jujube leaves, due to the progress of the disease and severe dryness of the skin, the patients in this group (15 individuals) chose to leave the study and 5 were omitted from the study due to non-compliance in appropriate use of the drug or avoiding the next visits. According to the results of the study on 60 patients (27 individuals in the placebo group and 23 individuals in the Christ’s thorn jujube total extract group), the cream containing Christ’s thorn jujube total extract was more efficient than the placebo in improving of dryness of skin (p<5×10-5). The cream containing Christ’s thorn jujube total extract alleviated all manifestations of the disease, but the placebo was only effective for removal of skin dryness (p<0.01). Also, the cream containing Christ’s thorn jujube total extract decreased the affected area one month after cessation of the treatment (p=7×10-4), but during this time, the effect of the drug in reducing itching, dryness and inflammation was not statistically significant (p<0.01). However, a significant reduction in mean amount of discharge from the lesions and lichenification was observed in the group using the cream with the total extract in comparison to the beginning of the study (p<0.01). The researchers came to the conclusion that the vanishing cream containing Christ’s thorn jujube total extract can be a suitable drug as adjuvant treatment for irritant contact dermatitis.

Twice per day, apply enough amounts on the affected area. The minimum course of treatment is 2 weeks. If the area is not washed, a new layer of cream can be applied.

Dosage form

Topical Cream



30 g tube in cardboard box

Patient information leaflet inside


  • Extract of Christ’s Thorn Jujube (Ziziphus spina-cristi)

Active Ingredients

  • quercetin
  • tannin
  • ebelin lactone
  • kristinenes A, B, C and D
  • muritine A
  • aglycone glycosides like beta-sitosterol, methyl esters (like methyl palmitate, methyl stearate and methyl myristate)
  • oleanolic acid
  • maslinic  acid

Contraindications and Cautions

No specific contraindication.


Adverse Effects

So far, no adverse reaction has been registered.

Drug Interaction

No reported drug interaction.

Administration during Pregnancy and Lactation

Safe for administration during pregnancy and lactation.

Further Notes

  • Complete the course of treatment.
  • Keep Dermatin Topical Cream, like all other medication, away from sight and reach of children.
  • Tightly close the tube after application and keep the medicine away from light and below 25°C.
  • Keep this leaflet; you may need to read it again.


Based on presence of 0.025% quercetin in the product.