CM Barij Topical Lotion

Relief of pain in knee osteoarthritis

Relief of musculoskeletal pain

Stretching of tendons


Osteoarthritis is the most common joint disease worldwide.  Some of the risk factors for the disease include age, obesity and a history of trauma. Patients often complain of pain, stiffness of the joints, morning stiffness and limited range of motion. For the treatment of every single patient with osteoarthritis there needs to be a separate individualist approach. Treatments include non-pharmacological methods (such as training sessions, exercise programs to maintain range of motion and muscle strength, use of assistive devices, weight management and nutritional supplements), pharmacological (such as topical and oral painkillers) and surgical procedures.

Menthol is one of the active ingredients of mint (Mentha spicata) and its counter-irritant and topical analgesic effects are well documented. When applied to the skin, mint essential oil or menthol stimulates the nerves which perceive cold, while simultaneously suppressing those for pain.

According to results of the studies conducted on animals, menthol produces antinociceptive effects by activating the endogenous opioid system or to some extent by having local anesthetic reactions without any anti-inflammatory effects. Moreover, mint essential oil subdues muscle contractions which occur as a result of serotonin and substance P release.

According to results of animal studies, celery essential oil has anti-inflammatory, anti-spasmodic and relaxant effects. Mint essential oil has anti-inflammatory and anti-spasmodic effects.

In a survey of the analgesic and anti-inflammatory effects of celery and mint essential oils and their mixture, examined by carrageenan test in rat and mice, significant local anti-inflammatory effects were attributed to these essences and their mixture. Mint essential oil and celery-mint essential oils mixture significantly suppress pain in the first phase of formalin test which is a neurogenic pain and is caused as a result of direct stimulation of nerves. Moreover, mint essential oil, celery essential oil and their mixture showed significant suppressive effects on the pain in the second phase of formalin test which is an inflammatory pain.

In a double-blind, placebo-controlled clinical trial, 102 patients with knee osteoarthritis were randomly divided into three groups of mint lotion, mint-celery lotion (C.M Barij Topical Lotion) and the other one with placebo lotion, each to be treated4 times a day topically. Further examinations were performed 1, 2, 3 and 4 weeks later after the first examination and the patients’ pain intensity during level walking, climbing stairs, descending stairs, sleeping, sitting down and ascending a slope were evaluated and data were analyzed using statistical tests.

According to results of this trial, 2 and 4 weeks after the start of the treatment, the effect of mint essential oil and C.M Barij Lotion on pain intensity reduction during level walking, showed significant difference to placebo (p<0.01). Additionally, C.M Barij Lotion showed relatively better effects on pain intensity during level walking and sitting down in comparison with mint lotion (although it was not statistically significant). Two weeks after the start of the treatment, in C.M Barij Topical Lotion group, pain intensity during sleeping reduced significantly in comparison with mint lotion and placebo groups (p<0.01).

Depending on the area affected, apply a suitable amount of CM Barij Lotion by gently messaging it on the skin, four times daily.

  • Topical Lotion
  • 15 ml drop with dropper in cardboard box
  • Patient information leaflet inside


  • Essential oils of celery (Apium graveolens)
  • mint (Mentha spicata)

Active Ingredients

  • menthol
  • menthone
  • limonene
  • carvone


  • Pregnancy, lactation, children
  • Presence of any wound or injury on the painful area

Adverse Effects

If applied as instructed, no serious side effects have been detected so far. However, skin allergic reactions such as tingling, pruritus, skin rash and photosensitivity have been rarely reported in susceptible patients.


Drug Interaction

No drug interaction has been reported so far.


Administration during Pregnancy and Lactation

Not to be used during pregnancy and lactation.

Further Notes

  • For external use only. Not edible.
  • Keep CM Barij Lotion, like all other medications, away from sight and reach of children.
  • After applying CM Barij Lotion, avoid bandaging or covering the area.
  • It is recommended NOT to apply CM Barij Lotion before bedtime.
  • Seal the container tightly immediately after application, and store it away from light, in 15-30°C.
  • Keep this leaflet; you may need to read it again.

Based on the presence of at least 55 mg (-)-carvone and at least 54 mg (+)-limonene per ml.