Capex Topical Cream

Adjuvant treatment for:

osteoarthritis, rheumatoid arthritis

post-herpetic neuralgia

alleviation of diabetic neuropathy pain

pain and spasm in shoulder, arms, backbone and legs

The neuropeptide substance P is involved in the inflammation and pain in arthritis; capsaicin serves to deplete this substance. In a study on patients with osteoarthritis and rheumatoid arthritis, researchers came to the conclusion that capsaicin cream 0.025% is an efficient and safe treatment for arthritis.

It so seems that capsaicin specifically stimulates non-myelinated C fibers and results in release of substance P. Prolonged administration of capsaicin inversely depletes reservoirs of substance P and probably other neurotransmitters from sensory nerve terminals. This results in reduction or elimination of transmission of pain stimulations from peripheral nerves to the higher centers. In most clinical trials, in patients suffering post herpetic neuralgia, diabetic neuropathy or osteoarthritis, adjuvant treatment with topical capsaicin has resulted in more efficient management of pain and no severe systemic adverse reaction has been reported.

Capsaicin specifically affects primary afferent sensory nerves, so as to cause –probably through a direct reaction with the ion-receptor complex in the membrane– opening of specific ion channels. Those nerves sensitive to capsaicin are involved in perception of pain and are responsible for the neurologic share of the inflammatory response and may as well have efferent function in target peripheral tissues. Apart from stimulative effects, capsaicin is capable of having analgesic and anti-inflammatory effects.

Up to 4 times per day, apply a small amount of the product to the painful spot, continue for at least 2 weeks. Little clinical data exists for more than 8 weeks of application.

  • Cream
  • 30 g tube bottle in cardboard box
  • Patient information leaflet inside

capsaicin, 6,7-dihydrocapsaicin, nordihydrocapsaicin


  • presence of wound in the painful area,
  • history of sensitivity to pepper and paraben,
  • children younger than 6 years of age.

Adverse Effects

The most important adverse reaction is dermal allergy in predisposed individuals, in which case the medication needs to be discontinued and a physician or pharmacist consulted. Burning exists, especially in the first week of administration, which is usually transient and does not indicate allergy to the medicine. Application of olive oil before or after application can alleviate the burning.

Drug Interaction

No reported drug interaction. 

Further Notes

  • Before using Capex Topical Cream, apply some to the inner forearm in the proximity of your wrist. In case no sign of dermal allergy occurs within 12-24 hours, including redness, itching, burning or rash, you may use Capex Topical Cream for the recommended duration of time.
  • Use disposable gloves when applying Capex Topical Cream and take extra care not to touch your eyes or other mucous membranes.
  • After applying Capex Topical Cream, avoid physical exercise and also heating the area.
  • Avoid continuous use of Capex Topical Cream on the same spot; to avoid damage to sensory nerves of the area, use it alternately.
  • The color of the product can range from light orange to dark, which is natural and does not affect the efficacy of the drug.
  • Keep Capex Topical Cream, like all other medication, away from sight and reach of children.
  • Tightly close the tube after application and keep the medicine away from light and in 25°C.
  • Do not use expired products.
  • Keep this leaflet; you may need to read it again.

Based on presence of 0.034-0.046 percent capsaicin in the product.