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Related Article Myrtex Topical Solution 5%
MYRTEX Topical Solution
1 and 8 cineol, -pinene, linalool, limonene, myrtenyl acetate
Pharmacological effect and mechanism of effect:
Recurrent Aphthous Stomatitis is one of rifest oral lesions. It is estimated that 20% of world population are afflicted with this condition some time during their lives. It is marked by recurrent painful rashes in the mouth and the oral cavity. It is more common during winter and spring. Underlying causes are usually divided into etiological causes (bacteria, viruses, genetic factors, iron deficiency, deficiency of B group vitamins, immunological disorders, etc) and intensifying causes (allergic response, trauma, mental causes, hormone imbalance, etc). Successful treatment should include correct diagnosis and controlling of underlying causes with the aim of hampering the expansion of rashes and reducing their duration and soreness. Due to the obscurity of causes and the emphasis of the existing treatment procedures on alleviating symptoms, however, most these procedures don’t render satisfactory results.
Using herbal medicine for disinfecting oral rashes, alleviating inflammations of oral tissue, alleviating tooth-ache and treating asthenia gum has been mentioned in texts of Iranian traditional medicine. Myrtus communis extract has antibacterial effects and it has been recommended for treatment of minor aphta precisely because of its bactericidal character. Also due to its antigenotoxic effects and removal of free radicals, myrtus communis has long been considered a possible remedy for recurrent aphthous stomatitis.
In a double-blind clinical test conducted with continuous sampling, 137 patients suffering from minor aphtha each were placed, according to their time of referring to the hospital, in one of the three groups: group A (treated with myrtex topical solution, which is a 5% solution of myrtus communis extract), group B (treated with 10% solution of myrtus communis extract) and group C (treated with placebo). From the day of their referring to the hospital until one day after complete disappearance of the lesion, these patients placed a piece of cotton wool dabbed with 10 drops of their respective medicine on the aphtha rash and kept it there for 20-30 seconds 5 or 6 times a day. Each patient underwent clinical examination one week after the start of his/her respective treatment at the earliest; and the time taken until the disappearance of lesions and accompanying pain was recorded in a special questionnaire.
According to the results of this test, the average time taken to the disappearance of soreness and burn sensation of minor aphtha rashes was 2.6 days for group A, 4.7 days for group B and 4.1 days for group C. there was thus a statistically significant difference between groups with regard to the average time taken to recovery (P<0.0005). The difference between group A and group B (P<0.001) and the difference between group A and group C (P<0.05) were particularly significant but no statistically meaningful difference could be perceived between group B and group C (P=0.44). The average time to total healing of lesions was 5.4 days for group A, 7.5 days for group B and 7.3 days for group C. There was thus a statistically significant difference between groups A and B (P<0.01) and between group A and C (P<0.05), while the difference between groups B and C was not statistically meaningful (P=0.92).
Researchers arrived to the conclusion that myrtex topical solution is effective in reducing the duration and the soreness of minor aphtha rashes. No toxicity or side-effects were reported for the solution.
In another double-blind, controlled, randomized clinical test, 45 patients afflicted with recurrent aphthous stomatitis were given either tooth pastes containing myrtus communis 5% extract or ordinary tooth pastes. They were asked to apply the tooth pastes 4 times a day for 6 consecutive days. Values of the 5 parameters "changes in the size of lesions", "level of soreness", "amount of erythema and exudate", "oral health profile" and "patient's general assessment of the treatment" were recorded before and during the course of treatment (in the mornings of the second, the fourth and the sixth day). Results are indicative of considerable reduction (statistically speaking) of size of lesions (P<0.001) and intensity of pain (P<0.05); and of erythema and exudates (P<0.001). Oral health profile of the group who received Myrtus communis extract substantially improved (p<0.001), and this was also true of the general assessment of the treatment as reported by patients in that group (p<0.05) .No side-effects were reported for the extract.
Researchers arrived to the conclusion that Myrtus communis extract is effective in reducing the size and soreness of lesions caused by recurrent aphthous stomatitis; and in reducing the amount of exudate and in alleviating erythema; and in general in making life easier for patients afflicted with the disease.
dab a piece of cotton wool with 10 drops of myrtex solution and place it on the aphthus lesion for 20 to 30 seconds. Do this
5 or 6 times a day.
this medication should not be applied during pregnancy or breast-feeding. Not to be administered to children or to cancer patients
as long as guidelines on dosage and usage are observed no side-effects are to be expected.
No interference with other drugs reported thus far
• Consult your physician before use
• Better results can be expected if usage is started once the initial signs of aphthous are recognized.
• A burning sensation followed by topical anesthesia is normal once the dabbed cotton wool is placed on the lesion.
• Don’t keep the dabbed cotton wool on the lesion for longer than recommended
• Like other drugs, keep out of the reach of children
• Recap after use and keep away from light in a temperature between 15 to 30 Celsius