Acne is the most prevalent chronic skin condition in puberty and adolescence, which manifests itself as non-inflammatory (whitehead and blackhead comedones) and inflammatory (papule, cyst and nodule) lesions. Acne and its dermal impressions have psychological effects on the suffering individuals. Clinically, acne is categorized into two groups: in the first group, the condition is mild to moderate and lesions are present only in the visage and there is no scar. In the second group, the condition is usually moderate to severe and the lesions affect the trunk as well and scarring might be present. Causes of acne include: increase in sebum production, blockage of follicular duct, follicular hyperkeratinization, Propionibacterium acnes and inflammation.
Ferula has antimicrobial and antifungal properties. Lavender has been topically used to treat acne, prevent scarring in the face and formation of spots in the visage and it the trunk. Lavender is one of the most valuable essential oils (usually coupled with bergamot) in treatment of acne. Lavender inhibits the bacteria responsible for skin infections, relieves skin, helps balance sebum production and prevents scarring.
In a double-blind clinical trial, to compare the efficacy of 3 lotions containing various amounts of essential oils of ferula and lavender with clindamycin solution 1.2%, 137 patients with acne were randomly divided into 4 treatment groups: group A (clindamycin solution 1.2%), group B (lotion containing equal amounts of essential oils of ferula and lavender 1%), group C (Galix Topical Lotion 5%, containing equal amounts of essential oils of ferula and lavender), and group D (lotion containing equal amounts of essential oils of ferula and lavender 3%). The patients were asked to apply twice a day, a few drops of the lotion to the area affected with acne. The patients were examined in 4 sessions within 3-week intervals by skin specialists. At the end of the study, to evaluate the general therapeutic outcome at each stage, the process of change in symptoms was again scored and patients were divided into 4 groups: no response, moderate, fair and excellent. The analysis of the data gathered from this study showed that Galix Topical Lotion 5%, which contained equal amounts of essential oils of ferula and lavender, had better results in reduction of inflammatory symptoms of acne and the degree of improvement in the Galix group had statistically significant difference with the other groups (p<0.08%)